Ethylene Oxide

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of ethylene oxide.

Details

Title: Toxicological Profile for Ethylene Oxide

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on these hazardous substances supports public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): 1/22/2020; 12/26/2021 (inhalation MRL update)

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft of this profile was made available for public comment in 2020.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 7

Primary Disciplines or Expertise: Toxicology, Toxicological pathology, Epidemiology, Environmental Health, Chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
MDPhD
Current Position Title
Professor
Organizational Affiliation(s)
Veterinary Integrative Biosciences
College of Vet Medicine & Biomedical Sciences
Texas A&M University
Areas of Expertise, Discipline, Relevant Experiences
  • Pharmacology
  • Toxicology
  • Risk assessment methods for carcinogens
  • Hepatic toxicity
  • DNA damage and repair
  • Mutagenesis
  • Carcinogenesis
  • Mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor
Organizational Affiliation(s)
Professor, Department of Environmental Health
Professor, Department of Epidemiology
Rollins School of Public Health
Emory University
Areas of Expertise, Discipline, Relevant Experiences
  • Statistical modeling
  • Environmental health
  • Epidemiology
  • Pesticides in relation to neurodegenerative diseases
  • Adult lead exposure and cancer
  • PFOA and a variety of diseases
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
Current Position Title
Group Lead, Ambient Aire Monitor Group
Organizational Affiliation(s)
Office of Air Quality Planning & Standards
U.S. Environmental Protection Agency
Areas of Expertise, Discipline, Relevant Experiences
  • EPA expert on EPA national ambient air monitoring networks for multiple pollutants
  • Particular expertise on ethylene oxide air levels
  • Eight publications from 2005-2019, cited by 428 other papers
Weinstock also has expertise crucial for review of 5.3.1 Potential for Human Exposure: Releases to The Environment: Air (air monitoring measurements & methods) to ensure that information is complete and accurate
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor Emeritus
Organizational Affiliation(s)
Environmental Health Sciences,
Lawrence Berkeley National Laboratory,
UC Berkeley School of Public Health
Areas of Expertise, Discipline, Relevant Experiences
  • Risk assessment
  • Model uncertainty and reliability in exposure/risk assessment
  • Environmental and occupational radioactivity
  • Mass transfer at environmental and human/environment boundaries
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Director, Analytical Chemistry & Pharmaceutics
Organizational Affiliation(s)
RTI International
Research Triangle Park
North Carolina, USA
Areas of Expertise, Discipline, Relevant Experiences
  • Biomarkers
  • Exposure assessment
  • Pharmacokinetics
  • Nanotoxicology
  • Biochemistry
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Associate Professor
Organizational Affiliation(s)
Pathobiology and Diagnostic Investigation
College of Veterinary Medicine;
Michigan State University
Areas of Expertise, Discipline, Relevant Experiences
  • Pathophysiology and pharmacology
  • Toxicology
  • Mechanisms of airway injury and systemic responses induced by inhalation exposures to pathogens, toxicants, and environmental pollutants
  • Role of diet and metabolic susceptibility in adverse cardiopulmonary responses to air pollutant exposure
  • Nanomaterials
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor
Organizational Affiliation(s)
University of Cincinnati
Areas of Expertise, Discipline, Relevant Experiences
Pathology and toxicology
Recommended by Scientific/Professional Society or General Public
No