September 2, 2024

Perfluoroalkyls (PFAS)

Toxicological Profile

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of perfluoroalkyls.

Details

Title: Toxicological Profile for Perfluoroalkyls

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances mostly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: HISA

Timing of Review (including deferrals): November 2014 and August 2017

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft will be made available for public comment in 2015. A draft of the revised profile will be made available for public comment in 2018.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials

MDMS

Current Position Title

Professor, Director of Academic Programs in Occupational Medicine

Organizational Affiliation(s)

Center of Excellence in Environmental Toxicology
University of Pennsylvania.

Philadelphia, Pennsylvania 19104

Areas of Expertise, Discipline, Relevant Experiences

Occupational and environmental skin diseases
Ultraviolet radiation effects on skin and eyes
Toxicity of polyaromatic hydrocarbons
PCBs
Organometals
Monomers used in plastics and resins, and other subjects
He is a recipient of the Kehoe Award of Merit from the American College of Occupational and Environmental Medicine

Recommended by Scientific/Professional
Society or General Public

Academic and Professional Credentials

PhD

Current Position Title

Professor

Organizational Affiliation(s)

Department of Environmental Medicine
University of Rochester School of Medicine

Areas of Expertise, Discipline, Relevant Experiences

The relationships between brain neurotransmitter systems and children’s neurodevelopment, and how such relationships are altered by exposures to environmental toxicants, including the role played by environmental neurotoxicant exposures in developmental disabilities and neurodegenerative diseases.

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Academic and Professional Credentials

PhD

Current Position Title

Professor Emeritus

Organizational Affiliation(s)

College of Pharmacy
Ohio State University
Columbus, Ohio

Areas of Expertise, Discipline, Relevant Experiences

Pharmacokinetics, particularly the construction and validation of mathematical models that describe or explain the kinetics of complex biological systems.

Interspecies scaling of pharmacokinetic model parameter values and xenobiotic metabolism.

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Academic and Professional Credentials

PhD

Current Position Title

Associate Professor

Organizational Affiliation(s)

Department of Pharmacology & Toxicology
Brody School of Medicine
East Carolina University

Areas of Expertise, Discipline, Relevant Experiences

Environmental and neural science
Environmental toxicology
Immunotoxicology

Her environmental developmental neuroimmunotoxicology research program explores relationships between biological organisms and their developmental responses after exposure to environmental toxicants. She has special emphasis research on early life exposure to a variety of agents that may affect the immune, nervous, and endocrine systems, resulting in altered development such as disease or disorder in childhood or later in life. Her expertise lies in how impacts on the immune system lead to downstream effects on the nervous system. She has numerous publications and research in the area of PFAS.

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Academic and Professional Credentials

PhD

Current Position Title

Professor of Epidemiology

Organizational Affiliation(s)

Brown University School of Public Health, with a joint appointment in Obstetrics and Gynecology in the Alpert Medical School, Providence, RI

Areas of Expertise, Discipline, Relevant Experiences

Areas of Expertise:

Editor for the American Journal of Environmental hazards in the workplace and community
Reproductive health outcomes
Environmental influences on cancer

Experience:

Dr. Savitz has done extensive work on health effects of nonionizing radiation, pesticides, drinking water treatment by-products, and perfluorinated compounds. He has:

Directed 30 doctoral dissertations and 15 master’s theses
Authored nearly 350 papers in professional journals
Editor author of three books
Editor at the American Journal of Epidemiology and as a member of the Epidemiology and Disease Control-1 study section of the National Institutes of Health
Current editor at Epidemiology
Previous president of the Society for Epidemiologic Research and the Society for Pediatric and Perinatal Epidemiologic Research
Previous President of the North American Regional Councilor for the International Epidemiological Association
Member of the National Academy of Sciences Institute of Medicine. From 2013-2017
Vice President for Research at Brown University

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Society or General Public