Trichloroethylene (TCE)

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of trichloroethylene (TCE).

Details

Title: Toxicological Profile for Trichloroethylene (TCE)

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): November 2013

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for Public Comment (how and when): A draft of this profile will be made available for public comment in 2014.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: Three or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD
DABT
Current Position Title
Research Scientist
Organizational Affiliation(s)
Office of Science, New Jersey Department of Environmental Protection, Trenton, NJ
Areas of Expertise, Discipline, Relevant Experiences
Areas of expertise:
Human health risk assessment and toxicology research on health effects of environmental contaminants

Experience:
Dr. Post currently serves on the EPA Science Advisory Board’s Exposure and Human Health Committee. She has served on the EPA SAB Trichloroethylene Review Panel. She is a member of the NJ Drinking Water Quality Institute, a legislatively mandated advisory body to NJDEP.

Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor
Organizational Affiliation(s)
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, Georgia
Areas of Expertise, Discipline, Relevant Experiences
  • Basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health
  • Volatile organic chemicals (VOCs) and pesticides
  • Low environmental exposures and cancer risk to humans
  • Drug-chemical interactions
  • Physiologically-based pharmacokinetic models, pyrethroid pesticides and children’s health
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
MD
PhD
Current Position Title
Professor Emeritus
Organizational Affiliation(s)
Leibniz Research Centre for Working Environment and Human Factors, Systems toxicology group, Dortmund, Germany
Areas of Expertise, Discipline, Relevant Experiences
  • Toxicology
  • Risk assessment
  • Genotoxic carcinogens
  • Occupational standard settings
Recommended by Scientific/Professional
Society or General Public
No

Resources

Guidelines for Peer Review of Toxicological Profiles
Guidelines for peer reviewers of toxicological profiles to enable ATSDR to address your comments.
CDC/ATSDR’s Response to Reviewers’ Comments for Toxicological Profile for Trichloroethylene (TCE)
Download
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The ISI/HISA Dissemination Itself
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Content Source:
Agency for Toxic Substances and Disease Registry